The draw was made today and the games will hold on 12 and 19 March, 2015.
| Everton | v | Dynamo Kiev |
| Zenit Saint Petersburg | v | Torino |
| Villarreal | v | Sevilla |
| Club Brugge | v | Besiktas |
| Dnipro Dnipropetrovsk | v | Ajax |
| Wolfsburg | v | Inter Milan |
| Napoli | v | Dynamo Moscow |
| Fiorentina | v | Roma |